Brief Description

L-165041 is a cell permeable PPARδ agonist which induces adipocyte differentiation in NIH-PPARδ cells.
Target: PPARδ
L-165041 displays more than 100-fold selectivity for both mouse and human PPARδ receptors over other subtypes. L-165041 reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. L-165041 raises plasma cholesterol levels in vivo, in insulin-resistant db/db mice. L-165041 is neuroprotective in models of cerebral infarction and Parkinson's disease.

Solubility

DMSO ≥100mg/mL; 1eq. NaOH ≥100mg/mL

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

White to off-white solid