Brief Description

PKI-587 is a potent inhibitor to PI3K-α, PI3K-γ, and mTOR (FRAP) with IC50 of 0.4 nM, 5.4 nM, and 1.6 nM, respectively. PKI-587 also exhibits potency against the most frequently occurring mutant forms of PI3Kα, notably the H1047R and E545K with IC50 of 0.6 nM and 0.6 nM, respectively. PF-05212384 inhibitory actions against PI3Ks and mTORs causes tumor cell growth inhibition in MDA-361 and PC3-MM2 cell lines with IC50 of 4 nM and 13.1 nM, respectively.

Solubility

DMSO

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Flash point

Storage conditions

Store at -20°C 2 years

Appearance: