Brief Description

PI 3-Kβ Inhibitor VI, TGX-221 is a cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-kinase β (IC50 = 0.005, 0.1, 5, and ≥3.5 μM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 μM. PI 3-Kβ Inhibitor VI, TGX-221 is an excellent tool for studying p110b-dependent responses in cells in vitro.

Solubility

DMSO ≥15mg/mL, Water <1.2mg/mL, Ethanol ≥3.8mg/mL

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

Light yellow to yellow solid