Brief Description

EPZ015666 is a potent, selective and orally bioavailable PRMT5 inhibitor with Ki of 5 nM, >20,000-fold selectivity over other PMTs.
IC50 value: 5 nM (Ki)
Target: PRMT5 inhibitor
EPZ015666 shows potent cellular activity that blocks symmetric dimethylation of SmD3 and inhibit proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. EPZ015666 (200 mg/kg, p.o.) displays robust anti-tumor activity in MCL xenograft animal models.

Solubility

38mg/ml in CH3OH

Melting point

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Density

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Flash point

Storage conditions

Store at -20°C 2 years

Appearance: