Brief Description

PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.
IC50 value: 3 nM/11 nM(Wt LRRK2/G2019S LRRK2)
Target: LRRK2 inhibitor
PF-06447475 was sufficiently potent in the LRRK2 whole cell assay (WCA; IC50=25 nM) (pS935 end point) to warrant additional profiling. Oral administration of PF-06447475 twice daily for 15 days was well tolerated at doses up to 60 mg kg-1 day-1 (31-fold Cave,0.24h; 70-fold Cmax) with only minimal alterations in RBC parameters, electrolytes, and food consumption without concurrent effects on body weight.

Solubility

DMSO: 33mg/mL

Melting point

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Density

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Flash point

Storage conditions

Store at -20°C 2 years

Appearance: