Brief Description

PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, less potent to PI3Kα/β/γ.
IC50 value: 10 nM(p110δ)
Target: p110δ inhibitor
PIK-294 shows distinct patterns of isoform selectivity to inhibit different subsets of class I PI3K isoforms (p110β, p110δ, and p110γ) and exhibits low sensitivity to p110α with IC50 of 10 μM). The m-phenol moiety of PIK-294 is able to penetrate the deep-affinity pocket of the ATP binding site, and thus increases in vitro inhibitory activity.

Solubility

200 mM in DMSO

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

White to off-white solid