Brief Description

AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM).
IC50 value: 1.8/3.1 uM(AdipoR1/2, Kd)
Target: AdipoR
in vitro: The treatment of C2C12myotubes withAdipoRon caused an increase in the phosphorylation of Thr 172 in the a-subunit of AMPK (aAMPK). AdipoRon at concentrations of 5–50 mM increased AMPK phosphorylation in a dose-dependent manner to almost the same extent as did adiponectin. Suppression of AdipoR1 by specific siRNA greatly reduced the increase in AMPK phosphorylation induced by AdipoRon. In the presence or absence of the submaximal concentration of adiponectin (15 ug/ml), AdipoRon increased AMPK phosphorylation in a dose-dependent manner, whereas AdipoRon did not increase nor decrease AMPK phosphorylation in the presence of the maximal concentration of adiponectin (50 ug/ml).
in vivo: Oral administration of AdipoRon (50 mg /kg body weight) for 10 days did not significantly affect body weight nor food intake in mice on a high-fat diet, but it did significantly reduce fasting plasma glucose and insulin levels as well as glucose and insulin responses during oral glucose tolerance tests in wild-type mice treated with AdipoRon.

Solubility

DMSO

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

White to off-white solid