Brief Description

VU 0361737 is a selective positive allosteric modulator at mGluR-4 (EC50 values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGluR-1, mGluR-2, mGluR-3, mGluR-6 and mGluR-7 receptors and displays weak activity at mGluR-5 and mGluR-8 receptors. Also a brain penetrant.

Solubility

Soluble to 100 mM in DMSO

Melting point

Boiling point

Density

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Flash point

Storage conditions

Store at -20°C 2 years

Appearance: