Brief Description

JNJ-40411813 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM.
IC50 value: 147 nM(EC50)
Target: mGlu2R
JNJ-40411813 displayed an optimal interplay between potency, selectivity, favorable ADMET/PK and cardiovascular safety profile, and central EEG activity. JNJ-40411813 has been investigated in the clinic for schizophrenia and anxious depression disorders.

Solubility

DMSO

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Storage conditions

Store at -20°C 2 years

Appearance: