Brief Description

BMS-806 (BMS 378806) is a small molecule gp120/CD4 inhibitor with an IC50 of median 5 nM.
IC50 Value: 5 nM
Target: HIV
BMS-806 (BMS 378806) was proved to be specific for HIV-1, with no activity against HIV-2 or simian immunodeficiency virus. BMS-806 (BMS 378806) is active against HIV-1 isolates irrespective of chemokine receptor preference. BMS-806 (BMS 378806) binds gp120, and changes in particular gp120 amino acid residues can alter the sensitivity of the virus to BMS-806 (BMS 378806). BMS-806 (BMS 378806) potently inhibited HIV-1 infection regardless of the particular chemokine receptor used.

Solubility

DMSO ≥80mg/mL; Water <1.2mg/mL; Ethanol ≥4.5mg/mL

Melting point

Boiling point

Density

Formula Weight:

Flash point

Storage conditions

Store at -20°C 2 years

Appearance:

White to off-white solid